A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction
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چکیده
منابع مشابه
A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction
Successful weight loss is variable for reasons not fully elucidated. Whether effective weight loss results from smaller reductions in energy expenditure during caloric restriction is not known. We analyzed whether obese individuals with a "thrifty" phenotype, that is, greater reductions in 24-h energy expenditure during fasting and smaller increases with overfeeding, lose less weight during cal...
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BACKGROUND Bone loss often accompanies weight loss induced by caloric restriction (CR), but whether bone loss accompanies similar weight loss induced by exercise (EX) is unknown. We tested the hypothesis that EX-induced weight loss is associated with less bone loss compared with CR-induced weight loss. METHODS Forty-eight adults (30 women; 18 men; mean +/- SD age, 57 +/- 3 years; and mean +/-...
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Energy expenditure decreases in response to weight loss. Although this phenomenon is likely driven, at least in part, by neuroendocrine adaptations to caloric imbalance, its underlying molecular mechanisms are not yet fully elucidated (1). Because adaptive thermogenesis intensifies and is sustained over time as weight loss increases (2,3), it is considered to mitigate weight loss. The variabili...
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The prevalence of type 2 diabetes mellitus (T2DM) and obesity in the western world is steadily increasing. Bariatric surgery is an effective treatment of T2DM in obese patients. The mechanism by which weight loss surgery improves glucose metabolism and insulin resistance remains controversial. In this review, we propose that two mechanisms participate in the improvement of glucose metabolism an...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2015
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db14-1881